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Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010

Received: 25 August 2016     Accepted: 26 September 2016     Published: 15 October 2016
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Abstract

Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126(China Center for Type Culture Collection, CCTCC)of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.

Published in Advances in Bioscience and Bioengineering (Volume 4, Issue 5)
DOI 10.11648/j.abb.20160405.12
Page(s) 51-58
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Coxsackievirus A16, Hand, Foot and Mouth Diseases, Phylogenetic Analysis

References
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[15] Mao Q, Wang Y, Yao X et al., Coxsackievirus A16: epidemiology, diagnosis, and vaccine. Hum Vaccin Immunother, 2014. 10 (2): 360-7.
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Cite This Article
  • APA Style

    Tingting Xu, Weixia Wang, Songya Lyu. (2016). Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Advances in Bioscience and Bioengineering, 4(5), 51-58. https://doi.org/10.11648/j.abb.20160405.12

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    ACS Style

    Tingting Xu; Weixia Wang; Songya Lyu. Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Adv. BioSci. Bioeng. 2016, 4(5), 51-58. doi: 10.11648/j.abb.20160405.12

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    AMA Style

    Tingting Xu, Weixia Wang, Songya Lyu. Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010. Adv BioSci Bioeng. 2016;4(5):51-58. doi: 10.11648/j.abb.20160405.12

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  • @article{10.11648/j.abb.20160405.12,
      author = {Tingting Xu and Weixia Wang and Songya Lyu},
      title = {Identification of a Novel Coxsackievirus A16 Strain Isolated from the Clinic HFMD Sample in Hubei Province in 2010},
      journal = {Advances in Bioscience and Bioengineering},
      volume = {4},
      number = {5},
      pages = {51-58},
      doi = {10.11648/j.abb.20160405.12},
      url = {https://doi.org/10.11648/j.abb.20160405.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20160405.12},
      abstract = {Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126(China Center for Type Culture Collection, CCTCC)of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.},
     year = {2016}
    }
    

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    AB  - Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126(China Center for Type Culture Collection, CCTCC)of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.
    VL  - 4
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Author Information
  • State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

  • State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

  • State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

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